7a:["$","p","p-5",{"className":"mb-4 leading-relaxed","node":{"type":"element","tagName":"p","properties":{},"children":[{"type":"text","value":"The fundamental pathology of CJD involves the conversion of the normal cellular prion protein (PrP","position":{"start":{"line":40,"column":1,"offset":3511},"end":{"line":40,"column":99,"offset":3609}}},{"type":"text","value":"^{"},{"type":"text","value":"C","position":{"start":{"line":40,"column":104,"offset":3614},"end":{"line":40,"column":105,"offset":3615}}},{"type":"text","value":"}"},{"type":"text","value":") into an abnormal, misfolded, and infectious isoform known as PrP","position":{"start":{"line":40,"column":111,"offset":3621},"end":{"line":40,"column":177,"offset":3687}}},{"type":"text","value":"^{"},{"type":"text","value":"Sc","position":{"start":{"line":40,"column":182,"offset":3692},"end":{"line":40,"column":184,"offset":3694}}},{"type":"text","value":"}"},{"type":"text","value":". PrP","position":{"start":{"line":40,"column":190,"offset":3700},"end":{"line":40,"column":195,"offset":3705}}},{"type":"text","value":"^{"},{"type":"text","value":"C","position":{"start":{"line":40,"column":200,"offset":3710},"end":{"line":40,"column":201,"offset":3711}}},{"type":"text","value":"}"},{"type":"text","value":" is a normal protein found on the surface of cells, particularly in the central nervous system. The misfolded PrP","position":{"start":{"line":40,"column":207,"offset":3717},"end":{"line":40,"column":320,"offset":3830}}},{"type":"text","value":"^{"},{"type":"text","value":"Sc","position":{"start":{"line":40,"column":325,"offset":3835},"end":{"line":40,"column":327,"offset":3837}}},{"type":"text","value":"}"},{"type":"text","value":" is resistant to degradation and accumulates in the brain. This accumulation triggers a cascade of events leading to neuronal cell death. The number of misfolded protein molecules increases exponentially as they induce more normal proteins to misfold. This process leads to the characteristic spongiform (sponge-like) changes in the brain, with the formation of numerous tiny vacuoles in the neuropil, neuronal loss, and the proliferation of glial cells (astrogliosis), ultimately causing severe neurological dysfunction.","position":{"start":{"line":40,"column":333,"offset":3843},"end":{"line":40,"column":854,"offset":4364}}}],"position":{"start":{"line":40,"column":1,"offset":3511},"end":{"line":40,"column":854,"offset":4364}}},"children":["The fundamental pathology of CJD involves the conversion of the normal cellular prion protein (PrP","^","C","",") into an abnormal, misfolded, and infectious isoform known as PrP","^","Sc","",". PrP","^","C",""," is a normal protein found on the surface of cells, particularly in the central nervous system. The misfolded PrP","^","Sc",""," is resistant to degradation and accumulates in the brain. This accumulation triggers a cascade of events leading to neuronal cell death. The number of misfolded protein molecules increases exponentially as they induce more normal proteins to misfold. This process leads to the characteristic spongiform (sponge-like) changes in the brain, with the formation of numerous tiny vacuoles in the neuropil, neuronal loss, and the proliferation of glial cells (astrogliosis), ultimately causing severe neurological dysfunction."]}]