Drugs for Peripheral Nervous System
A. Skeletal Muscle Relaxants:
- Peripherally acting:
- Neuro muscular blocking agents:
- Nondepolarizing (competitive) blockers:
- long acting: d-Tubocurarine, Pancuronium, Doxacurium, Pipecuronium
- Intermediate acting: Vecuronium, Atracurium, Cisatracurium, Rocuronium, Rapacuronium
- Short acting: Mivacurium
- Depolarizing blockers: Succinyl choline (suxamethonium), Decamethonium
- Nondepolarizing (competitive) blockers:
- Directly acting agents: Dantrolene sodium, Quinine
- Neuro muscular blocking agents:
- Centrally acting:
- Mephenesin congeners: Carisoprodol, Chlorzoxazone, Chlormezanone, Methocarbamol
- Benzodiazepines: Diazepam,
- GABA mimetic: Baclofen, Thiocolchicoside
- Central α2 agonist:
B. Local Anesthetics:
a. Based on structure:
- Esters: Cocaine, procaine, chloroprocaine, benzocaine, tetracaine
- Amides: Lignocaine, mepivacaine, bupivacaine, prilocaine, articaine, ropivacaine
b. Based on clinical use:
- Surface anaesthetics: Cocaine, lignocaine, tetracaine, benzocaine, oxethazaine, proparacaine, butylaminobenzoate
- Injectable anaesthetics:
- Short acting and low potency: Procaine, chloroprocaine
- Intermediate acting and potency: Lignocaine, mepivacaine, prilocaine, articaine
- Long acting and high potentcy: Tetracaine, bupivacaine, dibucaine, ropivacaine