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Drugs for Peripheral Nervous System

Drugs for Peripheral Nervous System

A. Skeletal Muscle Relaxants:

  1. Peripherally acting:
    • Neuro muscular blocking agents:
      • Nondepolarizing (competitive) blockers:
        • long acting: d-Tubocurarine, Pancuronium, Doxacurium, Pipecuronium
        • Intermediate acting: Vecuronium, Atracurium, Cisatracurium, Rocuronium, Rapacuronium
        • Short acting: Mivacurium
      • Depolarizing blockers: Succinyl choline (suxamethonium), Decamethonium
    • Directly acting agents: Dantrolene sodium, Quinine
  2. Centrally acting:
    • Mephenesin congeners: Carisoprodol, Chlorzoxazone, Chlormezanone, Methocarbamol
    • Benzodiazepines: Diazepam,
    • GABA mimetic: Baclofen, Thiocolchicoside
    • Central α2 agonist:

B. Local Anesthetics:

a. Based on structure:
  1. Esters: Cocaine, procaine, chloroprocaine, benzocaine, tetracaine
  2. Amides: Lignocaine, mepivacaine, bupivacaine, prilocaine, articaine, ropivacaine
b. Based on clinical use:
  1. Surface anaesthetics: Cocaine, lignocaine, tetracaine, benzocaine, oxethazaine, proparacaine, butylaminobenzoate
  2. Injectable anaesthetics:
    • Short acting and low potency: Procaine, chloroprocaine
    • Intermediate acting and potency: Lignocaine, mepivacaine, prilocaine, articaine
    • Long acting and high potentcy: Tetracaine, bupivacaine, dibucaine, ropivacaine

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