Drugs affecting Blood

• Drugs used to reduce the coagubility of the blood.

Classification

1. Iron:
   • Oral Iron: Ferrous sulfate, Ferrous fumarate, Ferrous gluconate, Ferrous succinate, Ferrous aminoate, Ferric ammonium citrate, Ferric hydroxy polymaltose, Carbonyl iron, Iron-calicium complex
   • Parenteral Iron: Iron-dextran, Iron-sorbitol-citric acid, Ferrous sucrose, Ferric carboxymaltose
2. Maturition factors:
   • Vitamin B₁₂ Cyanocobalamin, Hydroxocobalamin, Methylcobalamin
   • Folic acid:
   Folinic acid (leucovorin, citrovorum factor)
3. Adjuvant haematinics: Copper, Pyridoxine, Riboflavin

1. Vitamin K:
   • K₁: Phytonadione (Phylloquinone)
   • K₃: Menadione, Acetomenaphthone, Menadione sodium bisulfite, Menadione sodium diphosphate
2. Miscellaneous: Fibrinogen (human) Antihaemophilic factor, Desmopressin, Adrenochrome monosemicarbazone, Ethamsylate, Rutin

1. Parenteral anticoagulants:
   • Indirect thrombin inhibitors: Heparin (unfractionated), Low molecular weight heparins (Enoxaparin, Reviparin, Nadroparin, Dalteparin, Parnaparin, Ardeparin), Fondaparinux, Danaparoid
   • Direct thrombin inhibitors: Lepirudin, Bivalirudin, Argatroban
2. Oral anticoagulants:
   • Coumarin derivatives: Bishydroxycoumarin (dicumarol), Warfarin sodium, Acenocoumarol (Nicoumalone), Ethyl-biscoum-acetate
   • Direct factor Xa inhibitor: Rivaroxaban
   • Oral direct thrombin inhibitor: Dabigatran, etexilate
3. In vitro anticoagulants: Heparin, Sod. edetate, Sod. citrate, Sod. oxalate
4. Fibrinolytics (Thrombolytics): Streptokinase, Urokinase, Alteplase (rt-PA), Reteplase, Tenecteplase
5. Antifibrinolytics (Antithrombolytics): Epsilon aminocaproic acid(EA CA), Tranexamic acid

1. Thromboxane synthesis inhibitor: Aspirin
2. Platelet CAMP enhancer: Dipyridamole
3. P2Y₁₂ receptor blockers: Ticlopidine, Clopidogrel, Prasugrel
4. GP II_b / IIIa antagonists: Abciximab, Eptifibatide, Tirofiban

1. HMG-CoA reductase inhibitors (Statins): Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin, Pitavastatin
2. Lipoprotein lipase activators (PPARα activators: Fibrates): Clofibrate, Gemfibrozil, Bezafibrate, Fenofibrate
3. Sterol absorbtion inhibitor: Ezetimibe
4. Bile acid sequestrants: Cholestyramine, Colestipol
5. Lipolysis and triglyceride synthesis inhibitor: Nicotinic acid