• Immunosuppressive drugs are drugs that inhibit or prevent the activity of the immune system.
• These drugs prevent your immune system from attacking healthy cells and tissues by mistake.
• They are also known as immunosuppressive agents, immunosuppressants and antirejection medications.
• Healthcare providers prescribe immunosuppressants to treat autoimmune diseases and Individuals who have undergone organ transplants or stem cell transplants, such as bone marrow transplants, receive immunosuppressants to prevent their immune systems from rejecting the transplanted organs.

Classification:

1. Calcineurin inhibitors: Cyclosporine (Ciclosporin), Tacrolimus
2. m-TOR Inhibitors: Sirolimus, Everolimus
3. Antiproliferative drugs: Azathioprine, Methotrexate, Cyclophosphamide, Chlorambucil, Mycophenolate mofetil
4. Glucocorticoids: Prednisolone
5. Biological agents:
   • TNFα inhibitors: Etanercept, Infliximab, Adalimumab
   • IL-1 receptor antagonist: Anakinra
   • IL-2 receptor antagonists: Daclizumab, Basiliximab
   • Anti-CD3 antibody: Muromonab CD3
   • Polyclonal antibodies: Antithymocyte antibody (ATG), Rho(D) immuneglobulin